Alisa Morss Clyne

Alisa Morss Clyne is currently an Associate Professor in the Fischell Department of Bioengineering at the University of Maryland, College Park. Dr. Clyne is director of the Vascular Kinetics Laboratory, which investigates integrated mechanical and biochemical interactions among cells and proteins of the cardiovascular system. She is particularly interested in how endothelial cell mechanotransduction changes in a diseased environment, and how fluid shear stress and substrate mechanics affect biochemical binding kinetics, transport, and signaling.


Dr. Clyne received her bachelor’s degree in Mechanical Engineering from Stanford University in 1996. She worked as an engineer in the GE Aircraft Engines Technical Leadership Program for four years, concurrently earning her Master’s degree in Mechanical Engineering from the University of Cincinnati. In 2006, she received her Doctorate in Medical and Mechanical Engineering from the Harvard-MIT Division of Health Sciences and Technology. In 2014, she completed the Executive Leadership in Academic Technology and Engineering (ELATE) program.

Dr. Clyne received the NSF CAREER award in 2008, an AHA National Scientist Development Grant in 2010, and the BMES-CMBE Rising Star award in 2011. She has received research and educational funding from NSF, NIH, AHA, Department of Education, the Nanotechnology Institute, and the State of Pennsylvania, and she has published in diverse journals including Lab on a Chip, Journal of Biomechanics, Annals of Biomedical Engineering, Tissue Engineering, Biophysical Journal, PLOSOne, JBC, and Circulation. She is a fellow of ASME and the AHA, and a member of ASEE, BMES, NAVBO, and SWE. Her teaching focuses on mechanical engineering applications in biological systems, and she founded several programs to enhance diversity within engineering.

Team members 


Samantha Hudgins

Position: Postdoctoral Research Associate

Research interestsMy research is focused on identifying the role nutrition plays in human health with regard to various intake levels as well as different macronutrient effects. In particular, my research focuses on how dietary glucose impacts vascular health via post-translational modification of regulatory proteins through the Hexosamine Biosynthesis Pathway.

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Pattie Mathieu

Position: Postdoctoral Research Associate

Research interests: My research is focused on understanding the role of vascular smooth muscle cell phenotype on regulating the contraction and stiffness of blood vessels. My current research focuses on understanding how perivascular adipose tissue influences vessel stiffness and smooth muscle cell contractility and elucidating the role of LRP-1 in regulating vascular cell phenotype and blood vessel stiffness.

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Gurneet Sangha

Position: Postdoctoral Research Associate

Research interests: Exercise has shown to have a curvilinear response on vascular function with low and high training volumes resulting in the manifestation of adverse vascular structure and function. My research interests are focused on better understanding the mechanisms of how exercise training variables (mode, intensity, frequency, duration) impact vascular hemodynamics and health during atherosclerosis progression

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Graduate students

Callie Weber

Position: Graduate Student

Research interests: My research is focused on identifying metabolic variances between endothelial cells of different race and sex. Specifically, I would like to elucidate the role both race and sex play in glucose metabolism in both healthy and diseased brain vasculature, with a focus on Alzheimer's Disease. 

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Bilal AbdulMoiz

Position: Graduate Student

Research interests: I am interested in understanding and exploiting transport mechanisms across the blood-brain barrier for the purpose of developing therapeutics for neurological disease such as Alzheimer's. I plan to utilize a combination of computational modeling and experimental data to further my understanding of the underlying mechanisms. 

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Jesse Vo

Position: Graduate Student

Research interests: My research is focused on creating novel in vitro models of various vascular anatomy. Specifically, these models aim to improve on existing models through more anatomically relevant features such as tissue composition (cell co-cultures) and structure (3D cultures).

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Undergraduate Students

Kaitlyn Albus

Position: Undergraduate student

Research interests: My research interests include the effects of different nutrition and hormone conditions on endothelial cell metabolism. Specifically, I would like to focus on observing the changes of EC metabolism by extracellular vesicle treatment. 

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Angela Sun

Position: Undergraduate student

Research interests: I am interested in understanding how different environmental conditions alter the endothelial cell metabolome and how these changes may be implicated in cardiovascular disease.

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Sophie Zic

Position: Undergraduate student

Research interests: I am interested in differentiating induced pluripotent stem cells in order to study metabolism in the blood-brain barrier, specifically the role of metabolism in the blood-brain barrier in Alzheimer’s disease. 

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Yusuf Mastoor

Position: Undergraduate student

Research interests: My research interests include understanding how diseased environments affect the development and metabolism of the vasculature, specifically with how smooth muscle cells and endothelial cells respond to induced stressors in novel model environments.

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Contact Information

Call: +1 301 405 7771




Fischell Department of Bioengineering

University of Maryland
4224 A. James Clark Hall 

8278 Paint Branch Drive

College Park, MD 20742

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Publications Statistics

80 Publications

1564 Citation Counts

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