Research papers

Journal Publications

  • Diaz Lantada A, Morss Clyne A. Bioprinting vascular complexity (In review)Swaminathan S, Hamid Q, Sun W, Morss Clyne A. Bioprinting of 3D breast epithelial spheroids for human cancer models (In review)

  • Garcia J, Basehore S, Morss Clyne A. Fibroblast growth factor-2 binding to heparan sulfate proteoglycans varies with shear stress in flow-      adapted cells. (In review)

  • Urbano R, Morss Clyne A. Stiff substrates enhance endothelial oxidative stress following protein kinase C activation. (In review)

  • Morss Clyne A, Darling E, Marcolongo M, Chahine N. (2018) Translating mechanobiology to the clinic Cellular and Molecular Bioengineering, in    press.

  • Urbano R, Furia C, Basehore S, Morss Clyne A. (2017) Stiff substrates increase inflammation-induced tension and permeability in endothelial monolayers. Biophysical Journal, 113(3): p. 645-655. 

  • Swaminathan S, Ngo O, Basehore S, Morss Clyne A. (2017) A vascular endothelial – breast epithelial cell co-culture model created from 3D cell structures. ACS Biomaterials Science and Engineering, 3(11): p 2999-3006.

  • Mathew J, Basehore S, Morss Clyne A. (2017) Fluid shear stress and fibroblast growth factor-2 increase endothelial cell-associated vitronectin. Applied Bionics and Biomechanics, Article ID 9040161.

  • Canver A, Morss Clyne A. (2017) Quantification of multicellular organization, junction integrity, and substrate features in collective cell migration. Microscopy and Microanalysis, 23(1), p. 22-33.

  • Morss Clyne A, Billiar K. (2016) Problem-based learning in biomechanics: advantages, challenges, and implementation strategies. Journal of Biomechanical Engineering, 138(7). Selected as Editors' Choice paper for 2016 (10 selected out of 168)

  • Canver A, Ngo O, Urbano R, Morss Clyne A. (2016) Endothelial cell collective migration depends on substrate stiffness via localized myosin contractility and cell-matrix interactions. Journal of Biomechanics, 49(8): p. 1369-80.

  • Urbano R, Morss Clyne A. (2016) An inverted dielectrophoretic device for analysis of attached single cell stiffness. Lab on a Chip, 16: p. 561-573.

  • Mathew J, Morss Clyne A. (2015) Fibroblast growth factor-2 does not rescue plasminogen system activity or capillary-like tube formation in endothelial cells on glycated collagen. Biochemistry and Biophysics Reports, 4: p. 104-110.

  • Figueroa D, Kemeny S, Morss Clyne A. (2014) Glycated collagen decreased extracellular matrix fibronectin alignment in response to cyclic stretch via interruption of actin alignment. Journal of Biomechanical Engineering, 136(10). Selected as Editors' Choice paper for 2014 (9 selected out of 187)

  • Kemeny S, Figueroa D, Morss Clyne A. (2013) Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress. PLoSOne, 8(6): e66176.

  • Kemeny S, Cicalese S, Figueroa D, Morss Clyne A. (2013) Glycated collagen and altered glucose increase endothelial cell adhesion strength. Journal of Cellular Physiology, 228 (8): p. 1727-36.

  • Arjunan K, Morss Clyne A. (2013) A nitric oxide producing pin-to-hole spark discharge plasma enhances endothelial cell proliferation and migration. Plasma Medicine 1(3-4): 279-293.

  • Patel N, Reisig K, Morss Clyne A. (2013) A computational model of fibroblast growth factor-2 binding in fluid flow. Annals of Biomedical Engineering 41(1): p. 154-171.

  • Morss Clyne A, FitzGerald GA. (2012) What great creation. Science Translational Medicine 4(154).

  • Yu M, Huang S, Yu KJ, Morss Clyne A. (2012) Dextran and polymer polyethylene glycol (PEG) coating reduce both 5 and 30 nm iron oxide nanoparticle cytotoxicity in 2D and 3D cell culture. International Journal of Molecular Sciences 13(5): p. 5554-70.

  • Arjunan K, Friedman G, Fridman A, Morss Clyne A. (2012) Non-thermal dielectric barrier discharge plasma induces angiogenesis through reactive oxygen species. Journal of the Royal Society Interface 9(66): p. 147-157.

  • Arjunan K, Morss Clyne A. (2011) Hydroxyl radical and hydrogen peroxide are primarily responsible for dielectric barrier discharge plasma-induced angiogenesis. Plasma Processes and Polymers 8 (12): p. 1154-64

  • Kemeny S, Figueroa D, Andrews A, Barbee K, Morss Clyne A. (2011) Glycated collagen alters endothelial cell actin alignment and nitric oxide release in response to fluid shear stress. Journal of Biomechanics 44(10): p. 1927-35.

  • Figueroa D, Kemeny S, Morss Clyne A. (2011) Glycated collagen impairs endothelial cell response to cyclic stretch. Cellular and Molecular Bioengineering 4 (2): p. 220-30.

  • Kemeny S, Morss Clyne A. (2011) A simplified implementation of edge detection in MATLAB is faster and more sensitive than Fast Fourier Transform for actin fiber alignment quantification. Microscopy and Microanalysis 17: p. 156-166.

  • Dobrynin D, Arjunan KP, Fridman A, Friedman G, Morss Clyne A. (2011) Direct and controllable nitric oxide delivery into biological media and living cells by a pin-to-hole spark discharge (PHD) plasma. Journal of Physics D: Applied Physics 44: 075201.

  • Buyukhatipoglu K, Morss Clyne A.(2011) Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation. Journal of Biomedical Materials Research Part A 96A (1): p. 186-195.

  • Morss Clyne A. Thermal processing of tissue engineering scaffolds. (2011) ASME Journal of Heat Transfer Special Issue on Advanced Thermal Processing 133(3): 034001.

  • Reisig K, Morss Clyne A. (2010) Fibroblast growth factor-2 binding to the endothelial basement membrane peaks at a physiologically relevant shear stress. Matrix Biology 29 (7): p. 586-93.

  • Buyukhatipoglu K, Chang R, Sun W, Morss Clyne A. (2010) Bioprinted Nanoparticles for Tissue Engineering Applications. Tissue Engineering 16 (4): p. 631-42.

  • Meghri NW, Donius AE, Riblett BW, Martin EJ, Morss Clyne A, and Wegst UGK. (2010) Directionally Solidified Biopolymer Scaffolds: Mechanical Properties and Endothelial Cell Responses. JOM 62 (7): p. 71-5.

  • Kalghatgi S, Friedman G, Fridman A, Morss Clyne A. (2010) Low dose non-thermal plasma treatment enhances endothelial cell proliferation through FGF-2 release. Annals of Biomedical Engineering 38 (3): p. 748-57.

  • Buyukhatipoglu K, Morss Clyne A. (2010) Controlled flame synthesis of αFe2O3 and Fe3O4 nanoparticles: effect of flame configuration, flame temperature and additive loading. Journal of Nanoparticle Research 12 (4): p. 1495-1508.

  • Buyukhatipoglu K, Jo W, Sun W, Morss Clyne A. (2009) The role of printing parameters and scaffold biopolymer properties in the efficacy of a new hybrid nano-bioprinting system. Biofabrication 1 (3): 035003.

  • Morss Clyne A, Edelman, ER. (2009) Vascular growth factor binding kinetics to the endothelial cell basement membrane, with a kinetics-based correction for substrate binding. Cytotechnology 60 (1): p. 33-44.

  • Buyukhatipoglu K, Miller TA, Morss Clyne A. (2009) Interaction of superparamagnetic, flame synthesized iron oxide nanoparticles with porcine aortic endothelial cells: toxicity, cellular uptake and proliferation studies. Journal of Nanoscience and Nanotechnology 9 (12): p. 6834-6843.

  • Morss Clyne AS, Zhu H, Edelman ER. (2008) Elevated fibroblast growth factor-2 increases tumor necrosis factor-a induced endothelial cell death in high glucose. Journal of Cellular Physiology. 217: p. 86–92.

  • Morss AS, Edelman ER (2007). Glucose modulates basement membrane absorption of fibroblast growth factor-2 via alterations in endothelial cell permeability. Journal of Biological Chemistry. 282(19): p. 14635-14644.

  • Edelman ER, Seifert P, Groothuis A, Morss A, Bornstein D, Rogers C (2001). Gold-coated NIR stents in porcine coronary arteries. Circulation. 103(3): p. 429-434.

Conference Presentations

Conference Presentations (* undergraduate)

  • Swaminathan S, Morss Clyne A. A microfluidic model of endothelial metabolism in flow. 2018 World Congress of Biomechanics (Invited Oral Presentation)

  • Morss Clyne A. Incorporating classroom based research experiences into biomechanical engineering education. 2018 World Congress of Biomechanics (Invited Oral Presentation)

  • Swaminathan S, Hamid Q, Sun W, Morss Clyne A. Bioprinting multi-cellular structures to advance vascularized 3D tissue engineering. 2018 Select Biosciences Bioengineering Conference (Invited Oral Presentation)

  • Basehore S and Morss Clyne A. Shear stress alters endothelial glucose metabolism. 2018 BMES Cellular and Molecular Bioengineering Conference (Poster Presentation)

  • Basehore S and Morss Clyne A. Endothelial cell shear stress mechanotransduction impacts glucose metabolism. Vascular Biology 2017 (Poster Presentation)

  • Morss Clyne A. Course-based undergraduate research experience (CURE) in biomechanical engineering.  2017 ASME SB3C (Invited Oral Presentation)

  • Swaminathan S, Hamid Q, Sun W, Morss Clyne A. Biofabrication of a 3D in vitro model to study breast-endothelial mechanobiology. 2017 ASME SB3C (Invited Oral Presentation)

  • Swaminathan S, Urbano B, Furia C, Morss Clyne A. Tumor Necrosis Factor-α and stiff arteries: bidirectional effects. 2016 NIH NHLBI Unraveling Vascular Inflammation: From Immunology to Imaging (Poster Presentation)

  • Morss Clyne A. Endothelial mechanobiology and glucose metabolism. 2016 Banff International Research Station for Mathematical Innovation and Discovery (BIRS) Workshop on Modeling and Quantifying Cell Function: 25 years of Cell Mechanobiology (Invited Oral Presentation)

  • Ngo O*, Swaminathan S, Morss Clyne A. A 3-D Model of Breast Tumor and Endothelial Cell Interactions. 2016 BMES Fall Meeting (Poster Presentation)

  • Basehore S, Morss Clyne A. Shear Stress Modulates Endothelial Cell Glucose Uptake and Endothelial Nitric Oxide Synthase OGlcNAcylation. 2016 BMES Fall Meeting (Invited Oral Presentation)

  • Swaminathan S, Ngo O*, Morss Clyne A. A 3D model of breast tumor-endothelial cell interactions. 2016 ASME SB3C (Oral Presentation)

  • Sedlak J, Morss Clyne A. Modification of a parallel plate flow chamber for analysis of endothelial response to disturbed flow. 2016 ASME SB3C (Poster Presentation)

  • Basehore S, Morss Clyne A. Effect of shear stress on glucose metabolism in pulmonary arterial hypertension. 2016 ASME SB3C (Poster Presentation)

  • Morss Clyne A. Enhancing biomechanical engineering education through problem based learning. 2016 ASME SB3C (Poster Presentation)

  • Houriet N*, Hallak M*, Morss Clyne A. A novel in vitro flow system for controlled fluid shear stress on 3D gel co-cultures. 2015 BMES Fall Meeting (Poster presentation)

  • Morss Clyne A. Problem-based learning in biomechanics. 2015 SB3C (Workshop)

  • Urbano R, Furia C, Osei-Owusu P, Morss Clyne A. Substrate stiffness exacerbates TNF-α-induced disruption of adherens junctions in endothelial cell monolayers. 2015 Cellular and Molecular Bioengineering Conference (Poster presentation)

  • Mathew J, Morss Clyne A. Fibroblast growth factor-2 increases plasminogen system activity through integrin-mediated vitronectin uptake. 2015 Cellular and Molecular Bioengineering Conference (Poster presentation)

  • Furia C*, Urbano R, Osei-Owusu P, and Morss Clyne A. In vitro and ex vivo substrate stiffness effects on endothelial permeability in response to TNF-α. 2014 BMES Fall Meeting (Poster presentation)

  • Erickson-Ludwig A and Morss Clyne A. Summer Diversity Program enhances female and underrepresented minority student academic performance and retention in the Drexel University College of Engineering ASEE 2014 (Oral presentation)

  • Canver A, Urbano R, Morss Clyne A. The impact of matrix glycation and mechanics on endothelial cell mechanotransduction, collective migration, and inflammatory response 2014 World Congress of Biomechanics (Invited oral presentation)

  • Morss Clyne A. Engineering the Mechanobiology Bridge: from Cells to Communities 2014 International Workshop on Multiscale Mechanobiology (Invited talk)

  • Morss Clyne A. Endothelial cell adhesion in health and disease 2013 American Society of Nephrologists Kidney Week (Invited talk)

  • Canver A, Morss Clyne A. Endothelial cell collective migration is enhanced on soft substrates 2013 BMES Fall Meeting (Poster presentation)

  • Patel N, Cai T*, Morss Clyne A. Fibroblast growth factor-2 binding to cell surface heparan sulfate proteoglycans increases in flow adapted endothelial cells 2013 BMES Fall Meeting (Poster presentation)

  • Mathew J, Morss Clyne A. Fibroblast growth factor-2 did not restore endothelial cell plasminogen system activity or capillary-like tube formation on glycated collagen 2013 BMES Fall Meeting (Poster presentation)

  • Urbano R, Morss Clyne A. Microfabrication of a dielectrophoretic device for high throughput analysis of single cell stiffness   2013 BMES Fall Meeting (Poster presentation)

  • Morss Clyne A. Biomimetic nanoparticle drug delivery systems. NEMB 2013 (Keynote presentation)

  • Cai T*, Patel N, Morss Clyne A. A computational model of fibroblast growth factor-2 binding to endothelial cells.  2012 BMES Fall Meeting (Poster presentation)

  • Figueroa D, Morss Clyne A. Glycated collagen alters basement membrane remodeling in  response to strain via decreased MMP activity. 2012 BMES Fall Meeting (Poster presentation)

  • Mathew J, Morss Clyne A. Glycated collagen decreases urokinase plasminogen activator (uPA) activity in endothelial cells. 2012 ASME Summer Bioengineering Conference (Poster presentation)

  • Patel N, Morss Clyne A. A computational model of fibroblast growth factor-2 binding to isolated and intact cell surface receptors. 2012 ASME Summer Bioengineering Conference (Poster presentation)

  • Yu M, Morss Clyne A. Dextran and PEG coating reduce nanoparticle toxicity to cells. 2012 ASME Summer Bioengineering Conference (Poster presentation)

  • Morss Clyne A. Low and high glucose inhibit endothelial cell response to shear stress. 2012 BMES-SPRBM (Oral presentation)

  • Morss Clyne A. Glycated collagen alters endothelial cell mechanotransduction. 2011 NAVBO Workshops in Vascular Biology (Oral presentation)

  • Figueroa D, Kemeny S, Morss Clyne A. Glycated collagen prevents endothelial cell response to cyclic stretch 2011 BMES Fall Meeting (Oral presentation)

  • Morss Clyne AM. Glycated collagen alters endothelial cell plasminogen system balance. 2011 BMES Fall Meeting (Oral presentation)

  • Cicalese S*, Kemeny S, Morss Clyne A. Ultra-low glucose, high glucose, and glycated collagen alter endothelial cell adhesion. 2011 BMES Fall Meeting (Poster presentation)

  • Olson MS, Gurian PL, Clyne AM, Shih WH, Shih W, and Lelkes P.  Nanotechnology in undergraduate education: environmental and health implications of nanotechnology 2011 ASEE Middle Atlantic Section Fall Conference (Oral presentation)

  • Arjunan K, Morss Clyne A. Non-thermal dielectric barrier discharge plasma induces angiogenesis through reactive oxygen species 2011 IEEE EMBC (Oral presentation)

  • Arjunan K, Morss Clyne A. Non-thermal dielectric barrier discharge plasma promotes vascularization through reactive oxygen species 2011 ASME Summer Bioengineering Conference (Oral presentation)

  • Kemeny S, Figueroa D, Morss Clyne A. Both hypoglycemia and hyperglycemia prevent endothelial cell actin fiber alignment to fluid shear stress 2011 ASME Summer Bioengineering Conference (Oral presentation)

  • Figueroa D, Morss Clyne A. Basement membrane collagen glycation prevents endothelial cell response to strain due to altered focal adhesion formation 2011 ASME Summer Bioengineering Conference (3rd place in PhD paper competition)

  • Yu M, Muzykantov V, Morss Clyne A. Iron oxide nanoparticles are less toxic to endothelial cells when coated with dextran and polyethylene glycol 2011 ASME Summer Bioengineering Conference (Poster presentation)

  • Kemeny S, Figueroa D, Morss Clyne A. Endothelial cell mechanical response is impaired by glycated collagen substrates 2011 Vascular Cell Biology Gordon Conference (Poster)

  • Kemeny S, Figueroa D, Morss Clyne A. Endothelial cell shear stress response is inhibited by glycated collagen 2011 BMES-SPRBM Conference on Cellular and Molecular Bioengineering (Rising star presentation)

  • Kemeny S, Figueroa D, Morss Clyne A. Endothelial cell mechanical response changes in a diabetic microenvironment. 2010 MRS Fall Meeting (Invited oral presentation)

  • Kemeny S, Morss Clyne A. Glycated substrate alters endothelial cell response to fluid shear stress. 2010 BMES (Oral presentation)

  • Morss Clyne A. Reactive oxygen species contribute to cell toxicity in a nano-bioprinting system. 2010 Biofabrication (Oral presentation)

  • Arjunan K, Dobrynin D, Friedman G, Morss Clyne A. A novel pin-to-hole spark discharge plasma produces nitric oxide for medical applications. 2010 ICOPS (Poster)

  • Morss Clyne A. Integrating new junior faculty into the Drexel University College of Engineering. 2010 ASEE (Oral presentation)

  • Buyukhatopoglu K, Sun W, Morss Clyne A. A hybrid nano-bioprinting device for tissue engineering. 2010 ASME NanoEngineering in Medicine and Biology (Oral presentation)

  • Weber H*, Figueroa D, Morss Clyne A. Collagen glycation alters endothelial cell response to cyclic strain. 2009 BMES (Poster)

  • Reisig K*, Morss Clyne A. Fibroblast growth factor-2 binding to endothelial basement membrane changes with shear stress. 2009 BMES (Poster)

  • Kalghatgi S, Fridman A, Friedman G, Morss Clyne A. Non-thermal plasma enhances endothelial cell proliferation through fibroblast growth factor-2 release. 2009 IEEE EMBC (Poster)

  • Morss Clyne, A. Obtaining the ideal faculty appointment: the job talk. 2009 ASME Summer Bioengineering Conference (Oral presentation)

  • Arjunan K, Dobrynin D, Fridman A, Friedman G, Morss Clyne A. A pin-to-hole spark discharge plasma generates nitric oxide and can be safely applied to an endothelial cell monolayer. 2009 ASME Summer Bioengineering Conference (Oral presentation)

  • Rajendran K, Manomohan G, Morss Clyne A. A dielectrophoretic device for studying single cell mechanics. 2009 ASME Summer Bioengineering Conference (Invited oral presentation, Mow symposium)

  • Kalghatgi S, Fridman A, Friedman G, Morss Clyne A. Non-thermal plasma enhances endothelial cell proliferation through fibroblast growth factor-2 release. 2009 ASME Summer Bioengineering Conference (Poster, 2nd place)

  • Buyukhatipoglu K, Chang R, Sun W, Morss Clyne A. Bioprinted nanoparticles for tissue engineering applications. 2009 ASME Summer Bioengineering Conference (Poster)

  • Figueroa D, Morss Clyne A. A cell stretching system to measure endothelial cell cyclic strain response on spatially defined basement membrane. 2009 ASME Summer Bioengineering Conference (Poster)

  • Kemeny S, Morss Clyne A. High glucose alters endothelial cell response to shear stress. 2009 ASME Summer Bioengineering Conference (Poster, Honorable Mention)

  • Kalghatgi S, Fridman A, Friedman G, Morss Clyne A. Non-thermal plasma enhances endothelial cell proliferation through fibroblast growth factor-2 release. 2009 IEEE ICOPS (Oral Presentation)

  • Buyukhatipoglu K, Morss Clyne A. Bioprinted nanoparticles for tissue engineering. IEEE CIMSA Special Session on Biomanufacturing (Invited Oral Presentation)

  • Morss Clyne, A. Effect of high glucose extracellular matrix alterations on endothelial cell plasminogen system balance. 2009 Vascular Matrix Biology and Bioengineering Workshop (Poster)

  • Buyukhatipoglu K, Miller TA, Morss Clyne A. In vitro toxicity and intracellular uptake of flame synthesized iron oxide nanoparticles: an alternative to wet synthesis methods. 2008 AIChE (Oral Presentation)

  • Buyukhatipoglu K, Miller TA, Morss Clyne A. Biocompatible, superparamagnetic, flame synthesized iron oxide nanoparticles: cellular uptake and toxicity studies. 2008 ASME IMECE (Oral Presentation)

  • Morss Clyne A, Edelman ER. Vascular cell response to basement membrane fibroblast growth factor-2 varies in high glucose. 2008 BMES (Poster)

  • Kalghatgi S, Fridman A, Friedman G, Morss Clyne A. Non-thermal dielectric barrier discharge plasma treatment of endothelial cells. 2008 IEEE EMBC (Oral Presentation)

  • Morss Clyne AS. Altered endothelial cell phenotype in diabetes: implications for growth factor and cytokine response. 2008 Gordon Conference on endothelial cell phenotypes in health and disease (Poster and Oral Presentation)

  • Morss Clyne AS, Edelman ER. Endothelial cell proliferation and survival in response to basement membrane fibroblast growth factor-2 depends on secondary mediators. 2008 9th International Conference on Angiogenesis (Poster and Oral Presentation)

  • Kalghatgi S, Friedman G, and Morss Clyne AS. Toxicity of non-thermal dielectric barrier discharge plasma treatment of endothelial cells. 2008 IEEE ICOPS  (Best student paper)

  • Morss Clyne AS, Zhu H, Edelman ER. Elevated glucose increases tumor necrosis factor-a induced endothelial cell death via fibroblast growth factor-2 release. 2008 Experimental Biology (Poster)

  • Manomohan G, Rajendran K, Morss Clyne AS. Design of a Dielectrophoretic Mechanical Testing Device. 2008 Materials Research Society Spring Meeting (Poster)

  • Morss AS, Jonas M, Edelman ER. Elevated basement membrane fibroblast growth factor-2 protects endothelial cells in high glucose. 2007 ASME Summer

 

Bioengineering Conference (Oral Presentation)

  • Morss AS, Edelman ER. Glucose modulates basement membrane fibroblast growth factor-2 via alterations in endothelial cell permeability. 2007 Experimental Biology (Poster)

  • Morss AS, Edelman ER. Glucose modulates basement membrane fibroblast growth factor-2 via alterations in endothelial cell permeability.  2006 HST Forum (Poster)

  • Morss AS, Shaw J. Diabetes and cardiovascular disease in native populations. 2005 HST Forum (Poster)

  • Morss AS, Edelman ER, Seifert P, Bornstein D, Rogers C. Biocompatibility comparison of stainless steel, gold-coated, and heat-treated gold-coated endovascular stents. 2001 Materials Research Society Fall Meeting (Oral Presentation)

Copyright © 2018 Vascular Kinetics Laboratory

Contact Information

Call: +1 301 405 7771

Email: aclyne@umd.edu 

 

Address

Fischell Department of Bioengineering

University of Maryland
4224 A. James Clark Hall 

8278 Paint Branch Drive

College Park, MD 20742

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80 Publications

1564 Citation Counts

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